EFAC Clinical Studies
Clinical Studies on EFAC
Real Science. Real Results.
Hype talks. Proof convinces.
Every claim about EFAC is backed by real science — not clever words or flashy marketing.
The studies below didn’t test EFAC in a lab. They tested it on real people with real pain.
Click a title. See the evidence. Decide for yourself.
➤ EFAC Cream Improves Balance in Knee OA Patients
Original Study Title: Effects of Treatment with a Cetylated Fatty Acid Topical Cream on Static Postural Stability and Plantar Pressure Distribution in Patients with Knee Osteoarthritis
Published In: Journal of Strength and Conditioning Research, Vol. 19(1), February 2005
Authors: Kraemer WJ, Ratamess NA, Maresh CM, et al.
Summary: This wasn’t theory. This was movement — tested in people whose joints had become their enemies. EFAC cream helped them stand stronger, sway less, and stay upright with confidence. That’s the difference pain relief makes when it’s real — and not a marketing claim.
Study Design:
- Type: Randomized, placebo-controlled clinical trial
- Participants: 40 adults with osteoarthritis in one or both knees
- Duration: 30 days
- Control: Placebo cream
Key Results:
- Reduced center-of-pressure (COP) sway and velocity
- Improved balance and postural control
- Placebo group showed no significant changes
➤ EFAC Cream Delivers Pain Relief and Mobility Gains — Starting in Just 30 Minutes
Original Study Title: Effect of a Cetylated Fatty Acid Topical Cream on Functional Mobility and Quality of Life of Patients with Osteoarthritis
Published In: The Journal of Rheumatology, Vol. 31(4), April 2004
Authors: Kraemer WJ, Ratamess NA, Anderson JM, et al.
Summary: Thirty minutes. That’s all it took for patients to move faster, feel better, and regain confidence. This study didn’t show a slow burn. It showed a turning point — fast. EFAC delivered mobility gains that didn’t just appear; they grew stronger with time.
Study Design:
- Type: Randomized, placebo-controlled clinical trial
- Participants: 40 adults with osteoarthritis in one or both knees
- Duration: 30 days
- Control: Placebo cream
Key Results:
- Faster stair climbing and chair-standing times after 30 minutes
- Increased knee range of motion
- Better performance in balance and reach tests
- Improvements grew over 30 days of continued use
➤ EFAC Cream with Menthol Reduces Pain and Improves Joint Function in Just 1 Week
Original Study Title: A Cetylated Fatty Acid Topical Cream with Menthol Reduces Pain and Improves Functional Performance in Individuals with Arthritis
Published In: Journal of Strength and Conditioning Research, Vol. 19(2), May 2005
Authors: Kraemer WJ, Ratamess NA, Maresh CM, et al.
Summary: One week. That’s all EFAC needed to show its strength — in joints across the body. Not just less pain, but more power, endurance, and range. No waiting. No wondering. Just results that speak louder than any label ever could.
Study Design:
- Type: Pre–post clinical trial
- Participants: 28 adults with arthritis in knees, elbows, or wrists
- Duration: 1 week
Key Results:
- Knee arthritis: 12% faster stair climbing, 16.5% more strength, 3.5% more range
- Elbow/wrist: 22–42% increase in muscular endurance
- Significant pain reduction across all groups
➤ Oral EFAC Supplement Improves Knee Flexibility and Function in Osteoarthritis
Original Study Title: Cetylated Fatty Acids Improve Knee Function in Patients with Osteoarthritis
Published In: The Journal of Rheumatology, Vol. 29(8), August 2002
Authors: Hesslink RJ Jr, Armstrong D III, Nagendran MV, et al.
Summary: This wasn’t a slight improvement. It was a tenfold leap in mobility compared to placebo. EFAC didn’t just help knees bend — it helped people move forward in life. Drug-free. Side-effect free. The kind of progress every patient deserves.
Study Design:
- Type: Randomized, placebo-controlled clinical trial
- Participants: 64 adults with chronic knee osteoarthritis
- Duration: 68 days
- Control: Placebo (vegetable oil)
Key Results:
- +10.06° gain in knee flexion (vs. +1.14° placebo)
- LAI function scores improved 5.4 vs. 2.1 placebo
- No change in knee extension
➤ EFAC Cream + Physical Therapy Reduces Neck Pain and Improves Function
Original Study Title: The Effect of Cetylated Fatty Esters and Physical Therapy on Myofascial Pain Syndrome of the Neck
Published In: Journal of Bodywork & Movement Therapies, Vol. 15(3), July 2011
Authors: Sharan D, Jacob BN, Ajeesh PS, Bookout JB, Barathur RR
Summary: Physical therapy works. But pair it with EFAC, and you supercharge the outcome. Faster pain relief. Sharper gains. More life lived between sessions. When real solutions combine, pain doesn’t stand a chance.
Study Design:
- Type: Randomized, double-blind controlled clinical trial
- Participants: 72 adults with myofascial pain syndrome (MPS) of the neck
- Duration: 4 weeks
- Control: Placebo cream + physical therapy
Key Results:
- Significant reduction in pain intensity
- Better neck function and less disability
- Improved quality of life
➤ Topical CFAs Reduce Knee Osteoarthritis Symptoms in Just One Week
Original Study Title: Short-Term Effect of Topical Cetylated Fatty Acid on Early and Advanced Knee Osteoarthritis: A Multi-Center Study
Published In: Archives of Rheumatology, Vol. 33(4), December 2018
Authors: Ariani A, Parisi S, Guidelli GM, et al.
Summary: Mild or severe — didn’t matter. EFAC went to work. In just one week, pain dropped, motion returned, and daily life got easier. And for those in worse shape? The results were even stronger. That’s what targeted, fast-acting relief looks like.
Study Design:
- Type: Multi-center, open-label clinical trial
- Participants: 113 adults with early to advanced knee OA
- Duration: 7 days
Key Results:
- Significant pain, stiffness, and function improvements after 1 week
- Effective in both early (grade 2) and advanced (grade 3) OA
- No adverse events reported
➤ Oral EFAC Improves Walking Distance and Knee Pain in Just 14 Days
Original Study Title: Oral EFAC Supplement Improves Walking Distance and Knee Pain in Just 14 Days
Presented At: Scripps Integrative Medicine Conference, 2007
Authors: Dr. Jay K. Udani, Betsy Singh, et al.
Summary: Two weeks in, EFAC users walked farther — a lot farther. The placebo group? They walked less. Pain dropped. Energy rose. And performance wasn’t a maybe — it was measurable. This is relief you don’t just feel. You prove it, step by step.
Study Design:
- Type: Randomized, placebo-controlled clinical trial
- Participants: 93 adults with moderate knee osteoarthritis
- Duration: 8 weeks
- Control: Placebo softgels
Key Results:
- +232 ft in 6-min walk at 2 weeks (placebo –119 ft)
- +537 ft by week 8 (placebo –106 ft)
- Pain scores dropped significantly by week 2 and kept improving
⚖️ Legal Disclaimer: This study was independently conducted and presented at a medical conference. It has not been published in a peer-reviewed journal. These results are shared as supportive data for the EFAC formula. Data on file.